Pteroylglutamic acid malabsorption in tropical sprue.
نویسندگان
چکیده
Pteroylglutamic acid (PGA) absorption was assessed in ten untreated tropical sprue (TS) and eight control subjects utilizing a marker perfusion technique. Physiologic concentrations of the vitamin (25 ng/ml) dissolved in iso-osmotic solutions containing either mannitol of glucose at a concentration of 55.6 mM were perfused on each subject on two consecutive days. A statistically significant difference in PGA absorption between TS and control subjects was obtained only when glucose was present in the perfusate. Thus, unequivocal malabsorption of PGA is demonstrable in all subjects with TS when more refined techniques than the ones applied heretofore are utilized.
منابع مشابه
Pteroylglutamic Acid Malabsorption in
Pteroylglutamic acid (PGA) absorption days. A statistically significant difference was assessed in ten untreated tropical in PGA absorption between TS and consprue (TS) and eight control subjects trol subjects was obtained only when gluutilizing a marker perfusion technique. cose was present in the perfusate. Thus, Physiologic concentrations of the vitamin unequivocal malabsorption of PGA is (2...
متن کاملPteroylglutamic Acid Malabsorption in Tropical
Pteroylglutamic acid (PGA) absorption days. A statistically significant difference was assessed in ten untreated tropical in PGA absorption between TS and consprue (TS) and eight control subjects trol subjects was obtained only when gluutilizing a marker perfusion technique. cose was present in the perfusate. Thus, Physiologic concentrations of the vitamin unequivocal malabsorption of PGA is (2...
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It is now recognized that abnormalities of small intestinal morphology and function in the tropics are found both in subjects with overt tropical sprue and in the asymptomatic indigenous population (Baker, Ignatius, Mathan, Vaish, and Chacko, 1962; Sprinz, Sribhibhadh, Gangarosa, Benyajati, Kundel, and Halstead, 1962; Lindenbaum, Alam, and Kent, 1966; Russell, Aziz, Ahmad, Kent, and Gangarosa, ...
متن کاملTreatment of overt and subclinical malabsorption in Haiti TABLE
It is now recognized that abnormalities of small intestinal morphology and function in the tropics are found both in subjects with overt tropical sprue and in the asymptomatic indigenous population (Baker, Ignatius, Mathan, Vaish, and Chacko, 1962; Sprinz, Sribhibhadh, Gangarosa, Benyajati, Kundel, and Halstead, 1962; Lindenbaum, Alam, and Kent, 1966; Russell, Aziz, Ahmad, Kent, and Gangarosa, ...
متن کاملTropical sprue: a riddle wrapped in a mystery inside an enigma
tropical countries in the last two centuries. Characterised by profuse diarrhoea, steatorrhoea, abdominal distension, mouth ulcers and weight loss, it is a malabsorption syndrome the aetiology of which has never been conclusively identified. The phrase “A riddle wrapped in a mystery inside an enigma (Winston Churchill)” applies very aptly to tropical sprue. During the period of European colonia...
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ورودعنوان ژورنال:
- Blood
دوره 45 4 شماره
صفحات -
تاریخ انتشار 1975